The USS Brattain (NCC-21166) was a 24th century Federation Miranda-class starship operated by Starfleet. During the mid-2360s this science vessel had a crew complement of thirty-five, among which included Captain Chantal Zaheva, her first officer Commander Brink, and Betazoid science advisor Andrus Hagan. In mid-2367, the Brattain mysteriously disappeared. It was re-discovered by the USS Enterprise-D, on stardate 44631.2, following a distress call sent twenty-nine days earlier.

The ship was found to be trapped in a Tyken’s Rift near an uncharted binary star system. An investigation discovered all but one of the ship’s crew died under circumstances of violent suicides and homicides, determined to be caused by severe REM deprivation. When last seen, the Brattain was still trapped within the rift.